P0300 on a 2022 Ford F 150 Super Crew Diesel

P0300 is a generic OBD2 powertrain code for random or multiple cylinder misfire. Unlike P0301 through P0308, it does not point to one specific cylinder, so the cause can be ignition, fuel, air, sensor, or mechanical.

Not your vehicle? See general P0300 info.

Most common causes on the 2022 Ford F 150 Super Crew Diesel

Ranked from 559 NHTSA owner complaints filed for this vehicle.

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1
Low-pressure fuel pump failure (open recall 25S75/25V455)
High severity
A large share of owners report the low-pressure in-tank fuel pump failing intermittently, causing loss of fuel pressure/flow, rough running, and stalling -- fuel starvation of this kind produces a misfire before a full stall.
Reported in 7 NHTSA complaints
Parts:fuel pump
2
Intake valve failure (2.7L EcoBoost valve-drop issue)
High severity
Owners describe a misfire warning with extreme vibration followed by a broken intake valve and catastrophic engine damage, and a related cold-start rattle from the intake valve area -- a known issue on 2021-2022 2.7L EcoBoost trucks.
Reported in 3 NHTSA complaints
3
Worn or fouled spark plugs
Low severity
Plugs out of gap or fouled with carbon misfire under load; inspect and gap/replace per service interval.
Common cause
Parts:spark plugs
4
Failing ignition coil(s)
Medium severity
A weak coil produces a cylinder-specific misfire that often worsens with heat; swap coils to isolate.
Common cause
Parts:ignition coil
5
Vacuum/intake leak
Medium severity
Unmetered air entering downstream of the MAF causes a lean misfire, especially noticeable at idle.
Common cause
6
Clogged or leaking fuel injector(s)
Medium severity
A partially clogged or dribbling injector delivers uneven fuel to a cylinder and produces a repeatable misfire.
Common cause
Parts:fuel injector
7
Carbon-fouled intake valves
Low severity
Direct-injection engines accumulate carbon on intake valves, disrupting airflow/atomization and causing misfire.
Common cause
8
EGR valve fault
Low severity
A stuck-open EGR valve over-dilutes the intake charge at idle, producing a rough idle/misfire.
Common cause
Parts:EGR valve

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These causes are aggregated from NHTSA owner complaints and general repair knowledge — this is not a diagnosis. P0300 on your car still needs shop confirmation before any repair.

Common symptoms

Flashing or steady check engine light
Rough idle
Shaking under acceleration
Loss of power
Fuel smell from exhaust

What to check before replacing parts

Scan for cylinder-specific misfire codes

Look for: A companion P0301–P0308 pins the misfire to one cylinder — start there. P0300 with no cylinder code points at something hitting several at once: fuel pressure, a large vacuum leak, or timing.

Inspect the spark plugs and coils

Look for: Pull the plugs: black/sooty = rich, oily = oil intrusion, white/blistered = lean or overheating, cracked porcelain or an out-of-spec gap = replace. Then swap a coil to another cylinder — if a cylinder-specific code follows the coil, the coil is bad.

Check fuel trims for a vacuum leak

Look for: High positive short- and long-term trims (worst at idle, improving as RPM rises) mean unmetered air is getting in. Smoke-test the intake and listen for hissing.

Verify fuel pressure

Look for: Compare running/cranking pressure to the vehicle spec. Low or dropping pressure starves multiple cylinders and reads as a random misfire — suspect the pump, filter, or regulator.

Compression / leak-down test if ignition and fuel check out

Look for: A cylinder 15%+ below the others, or leak-down hissing from the intake (intake valve), exhaust (exhaust valve), or oil filler (rings), means the misfire is mechanical — not a swap-in part.

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Matching symptoms

Car Runs Rough Flashing Check Engine Light