P0300 on a 2022 Ford F 150 Super Crew

P0300 is a generic OBD2 powertrain code for random or multiple cylinder misfire. Unlike P0301 through P0308, it does not point to one specific cylinder, so the cause can be ignition, fuel, air, sensor, or mechanical.

Not your vehicle? See general P0300 info.

Most common causes on the 2022 Ford F 150 Super Crew

Ranked from 559 NHTSA owner complaints filed for this vehicle.

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1
Cracked/broken intake valve (2.7L EcoBoost intake-valve recall)
High severity
Multiple owners report an explicit engine-misfire warning followed by catastrophic engine failure traced to a broken intake valve, matching the documented 2021-2022 F-150 2.7L EcoBoost recall.
Reported in 3 NHTSA complaints
2
Failing ignition coil(s)
Medium severity
One owner's rough-running engine was initially misdiagnosed and repaired as an ignition coil issue on a specific cylinder before the real cause (a valve failure) was found — showing coil failure is a real, if sometimes secondary, contributor on this engine.
Reported in 1 NHTSA complaint
Parts:ignition coil
3
Rough/unstable idle from carbon buildup on the throttle body or intake
Medium severity
An owner reports persistent shuddering, rough idle, and near-stalling in traffic with no dealer fix found, consistent with carbon fouling disrupting idle airflow/combustion on direct-injected engines.
Reported in 1 NHTSA complaint
4
Worn spark plugs
Low severity
The most common cause of a random misfire code across gasoline engines generally; check gap and electrode condition per the maintenance schedule.
Common cause
Parts:spark plugs
5
Clogged or leaking fuel injectors
Medium severity
Deposits or a leaking injector can starve or over-fuel an individual cylinder, producing an intermittent misfire.
Common cause
Parts:fuel injector
6
Vacuum leak (intake gasket or hose)
Medium severity
Unmetered air entering after the MAF sensor leans out the affected cylinder(s) and can present as a misfire at idle.
Common cause
7
EGR valve fault
Low severity
A stuck-open EGR valve over-dilutes the intake charge at idle/low load, a well-established contributor to misfire codes.
Common cause
Parts:EGR valve

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These causes are aggregated from NHTSA owner complaints and general repair knowledge — this is not a diagnosis. P0300 on your car still needs shop confirmation before any repair.

Common symptoms

Flashing or steady check engine light
Rough idle
Shaking under acceleration
Loss of power
Fuel smell from exhaust

What to check before replacing parts

Scan for cylinder-specific misfire codes

Look for: A companion P0301–P0308 pins the misfire to one cylinder — start there. P0300 with no cylinder code points at something hitting several at once: fuel pressure, a large vacuum leak, or timing.

Inspect the spark plugs and coils

Look for: Pull the plugs: black/sooty = rich, oily = oil intrusion, white/blistered = lean or overheating, cracked porcelain or an out-of-spec gap = replace. Then swap a coil to another cylinder — if a cylinder-specific code follows the coil, the coil is bad.

Check fuel trims for a vacuum leak

Look for: High positive short- and long-term trims (worst at idle, improving as RPM rises) mean unmetered air is getting in. Smoke-test the intake and listen for hissing.

Verify fuel pressure

Look for: Compare running/cranking pressure to the vehicle spec. Low or dropping pressure starves multiple cylinders and reads as a random misfire — suspect the pump, filter, or regulator.

Compression / leak-down test if ignition and fuel check out

Look for: A cylinder 15%+ below the others, or leak-down hissing from the intake (intake valve), exhaust (exhaust valve), or oil filler (rings), means the misfire is mechanical — not a swap-in part.

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Matching symptoms

Car Runs Rough Flashing Check Engine Light