P0300 on a 2017 Ford F 350 Super Crew

P0300 is a generic OBD2 powertrain code for random or multiple cylinder misfire. Unlike P0301 through P0308, it does not point to one specific cylinder, so the cause can be ignition, fuel, air, sensor, or mechanical.

Not your vehicle? See general P0300 info.

Most common causes on the 2017 Ford F 350 Super Crew

Ranked from 560 NHTSA owner complaints filed for this vehicle.

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1
Low compression from worn engine internals (rod bearing wear/catastrophic failure)
High severity
Rod-bearing knock and full engine replacements on this powertrain reduce cylinder compression and produce a rough-running, misfire-like condition before total failure.
Reported in 3 NHTSA complaints
2
High-pressure fuel pump (CP4) internal failure showering the fuel system with metal debris
High severity
Two owners had the CP4 pump disintegrate internally, sending metal shavings into the fuel rail and injectors and causing the engine to stall/misfire under acceleration.
Reported in 2 NHTSA complaints
Parts:high-pressure fuel pump fuel injectors fuel rail fuel filter
3
Loss of fuel delivery / low rail pressure causing surge and stall under load
High severity
Reduced-power warnings followed by a stall while towing or climbing a grade, with no stored codes, point to an intermittent fuel-supply shortfall.
Reported in 2 NHTSA complaints
Parts:fuel pump fuel filter
4
EGR valve fault or carbon buildup
Medium severity
One owner's teardown after a fuel-pump failure also found the EGR valve damaged, which can upset combustion stability and contribute to misfire.
Reported in 1 NHTSA complaint
Parts:EGR valve
5
Fuel injector fault
Medium severity
A momentary fuel-injector warning light preceded a fuel-system failure on this truck, consistent with an injector or injector-driver circuit issue that can cause misfire.
Reported in 1 NHTSA complaint
Parts:fuel injectors
6
Worn or fouled glow plugs causing cold-start/cylinder misfire
Medium severity
On the diesel 6.7L, glow plugs are the spark-plug analog; a weak or failed glow plug produces a cold-cylinder misfire, especially at startup.
Common cause
Parts:glow plugs
7
Charge-air/turbo intake leak
Low severity
A boost leak upstream of the cylinders leans out individual cylinders and can register as a random misfire under load.
Common cause
8
Carbon-fouled or coked injector tips
Medium severity
Diesel injector tip coking changes spray pattern and timing, producing an intermittent misfire that worsens with mileage.
Common cause
Parts:fuel injectors

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These causes are aggregated from NHTSA owner complaints and general repair knowledge — this is not a diagnosis. P0300 on your car still needs shop confirmation before any repair.

Common symptoms

Flashing or steady check engine light
Rough idle
Shaking under acceleration
Loss of power
Fuel smell from exhaust

What to check before replacing parts

Scan for cylinder-specific misfire codes

Look for: A companion P0301–P0308 pins the misfire to one cylinder — start there. P0300 with no cylinder code points at something hitting several at once: fuel pressure, a large vacuum leak, or timing.

Inspect the spark plugs and coils

Look for: Pull the plugs: black/sooty = rich, oily = oil intrusion, white/blistered = lean or overheating, cracked porcelain or an out-of-spec gap = replace. Then swap a coil to another cylinder — if a cylinder-specific code follows the coil, the coil is bad.

Check fuel trims for a vacuum leak

Look for: High positive short- and long-term trims (worst at idle, improving as RPM rises) mean unmetered air is getting in. Smoke-test the intake and listen for hissing.

Verify fuel pressure

Look for: Compare running/cranking pressure to the vehicle spec. Low or dropping pressure starves multiple cylinders and reads as a random misfire — suspect the pump, filter, or regulator.

Compression / leak-down test if ignition and fuel check out

Look for: A cylinder 15%+ below the others, or leak-down hissing from the intake (intake valve), exhaust (exhaust valve), or oil filler (rings), means the misfire is mechanical — not a swap-in part.

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Matching symptoms

Car Runs Rough Flashing Check Engine Light