P0300 on a 2016 Ford F 250 Supercab

P0300 is a generic OBD2 powertrain code for random or multiple cylinder misfire. Unlike P0301 through P0308, it does not point to one specific cylinder, so the cause can be ignition, fuel, air, sensor, or mechanical.

Not your vehicle? See general P0300 info.

Most common causes on the 2016 Ford F 250 Supercab

Ranked from 287 NHTSA owner complaints filed for this vehicle.

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1
Restricted fuel supply from a clogged fuel filter or failing lift pump
High severity
One owner reported the truck spraying fuel from the filter housing once the filter clogged; fuel starvation from a plugged filter or weak lift pump causes rough running and misfire across cylinders.
Reported in 2 NHTSA complaints
Parts:fuel filter fuel lift pump
2
Rough running / power loss during DPF active regeneration
Medium severity
Multiple owners describe a 'jackhammering' noise and loss of power specifically during exhaust regeneration events, consistent with unstable combustion from the extra post-injection fuel dosing used to regenerate the DPF.
Reported in 2 NHTSA complaints
3
Cylinder-specific mechanical failure (injector or valvetrain) causing loss of combustion
High severity
One owner's truck lost power and wouldn't restart; the dealer diagnosed a failure specific to cylinder #2 with resulting engine damage, a classic single-cylinder misfire root cause on the 6.7L.
Reported in 1 NHTSA complaint
Parts:fuel injector
4
Faulty knock sensor causing incorrect misfire/knock detection
Low severity
One owner's diagnostic showed a defective knock sensor; since knock sensor data feeds injection timing correction, a bad sensor can trigger false or genuine rough-running codes.
Reported in 1 NHTSA complaint
Parts:knock sensor
5
Faulty or leaking diesel fuel injector
Medium severity
A dribbling or clogged injector unbalances that cylinder's fuel charge, a very common diesel misfire cause even without a dramatic failure event.
Common cause
Parts:fuel injector
6
Low cylinder compression (worn rings, valves, or head gasket)
High severity
Mechanical wear reduces a cylinder's ability to build compression, causing that cylinder to misfire under load.
Common cause
7
EGR valve stuck or clogged with soot
Low severity
A malfunctioning EGR valve disrupts the air/exhaust mixture entering the cylinders, producing rough idle and misfire, especially on soot-prone diesels.
Common cause
Parts:EGR valve
8
Glow plug failure (cold-start misfire)
Low severity
A failed glow plug causes a cold cylinder to fire poorly until the engine warms, most noticeable on cold starts.
Common cause
Parts:glow plug

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These causes are aggregated from NHTSA owner complaints and general repair knowledge — this is not a diagnosis. P0300 on your car still needs shop confirmation before any repair.

Common symptoms

Flashing or steady check engine light
Rough idle
Shaking under acceleration
Loss of power
Fuel smell from exhaust

What to check before replacing parts

Scan for cylinder-specific misfire codes

Look for: A companion P0301–P0308 pins the misfire to one cylinder — start there. P0300 with no cylinder code points at something hitting several at once: fuel pressure, a large vacuum leak, or timing.

Inspect the spark plugs and coils

Look for: Pull the plugs: black/sooty = rich, oily = oil intrusion, white/blistered = lean or overheating, cracked porcelain or an out-of-spec gap = replace. Then swap a coil to another cylinder — if a cylinder-specific code follows the coil, the coil is bad.

Check fuel trims for a vacuum leak

Look for: High positive short- and long-term trims (worst at idle, improving as RPM rises) mean unmetered air is getting in. Smoke-test the intake and listen for hissing.

Verify fuel pressure

Look for: Compare running/cranking pressure to the vehicle spec. Low or dropping pressure starves multiple cylinders and reads as a random misfire — suspect the pump, filter, or regulator.

Compression / leak-down test if ignition and fuel check out

Look for: A cylinder 15%+ below the others, or leak-down hissing from the intake (intake valve), exhaust (exhaust valve), or oil filler (rings), means the misfire is mechanical — not a swap-in part.

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Matching symptoms

Car Runs Rough Flashing Check Engine Light